In a world where SSDs are still much more expensive than hard drives (around 5 times per GB), many user of desktop PCs opt to boot from a small SSD containing the operating system, and then install programs and data on a much larger HDD.
The Studio and MultiTerm installers should provide the option to choose an installation drive and path just as almost every other Windows application does. While there is a workaround for this, it requires a certain level of technical expertise that most translators should not be required to learn simply to install their CAT tools in a location of their choice. This method is also not officially supported by SDL Support.