Trados Studio 2021 SR1 does not load after update, even after rebooting/disabling antivirus/renaming plug-in folder

I updated to Studio 2021 SR1 today and the software now refuses to load. The initial start-up box opens, it gets as far as "opening plugins" and then cuts out entirely, failing to open.

I have uninstalled and reinstalled, tried a software repair, renamed the plug-ins folder and disabled my antivirus, all to no effect.

Please help!

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