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Could you please be more precise? When does this happen?
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This happens when I open a new file to translate, I get an error message: 
And when I enter the new access path to the TMs, Trados shuts down.
Is the new path fully accessible for the user, which has installed Trados?
Otherwise try to say "Abbrechen", then delete the TM from the project and other places and finally add it again from the proper path.
_________________________________________________________
When asking for help here, please be as accurate as possible. Please always remember to give the exact version of product used and all possible error messages received. The better you describe your problem, the better help you will get.
Want to learn more about Trados Studio? Visit the Community Hub. Have a good idea to make Trados Studio better? Publish it here.