Object reference not set to an instance of an object

I use Studio 2015 and this error message appears quite often. I tried to reset the the window layout & to delete the xml files from C:\Users\Your username\AppData\Roaming\SDL\SDL Trados Studio\11.0.0.0 as Jerzy suggested, but it helped just for a while. I also repaired the installation. But with no effect. When this message appears, I have to restart Studio to continue working. I did reorganize my TM´s too. 

Any ideas what could cause this problem? Thank you!