Error message: Exception has been thrown by the target of an invocation. Can't update TMs.

I'm using Trados Studio 2015 SR2 on Windows 10. This message is being thrown up every time I try to confirm a translated segment, which means my TMs are not being updated. I have no problem saving the XLIFF or target files, but the fact that my TMs are not being updated is a major issue, because I'm working on a project with over 60 files and I'm risking inconsistencies without them, quite apart from having to enter repeated text manually. 

Can anyone here help, please?

Thanks

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